Welcome to the Rileys. Trauma transforms us. Years after their teenage daughter’s death, Lois and Doug Riley, an upstanding Indiana couple, are frozen by estranging grief. She isolates herself in their immaculate suburban home. He philanders with a local waitress, anesthetizing pain with easy passion. When he loses his mistress to cancer, Doug, beset by further heartache, escapes to New Orleans on a business trip. Compelled by urgencies he doesn’t understand, he insinuates himself into the life of an underage hooker, becoming her platonic guardian. Meanwhile, Lois summons all of her remaining force to overcome agoraphobia and venture south to reclaim her marriage.